Centurion: South Africa claimed a convincing 107-run victory over England despite the tourists showing fight with the bat on the fourth day of the first Test.
The tourists, needing a record chase of 376 to win, resumed on 121-1 but were bowled out for 268, with Kagiso Rabada taking 4-103 in Centurion on Sunday.
A collapse of 7-64 sealed victory for South Africa, despite 84 from Rory Burns and Joe Root's 48.
The second Test of the four-match series begins on Friday.
It would have required a huge effort from England to secure victory on a wearing pitch but once the second new ball was taken, wickets fell quickly.
While both Root and Jos Buttler were able to bat despite being ill on Saturday, no batsman could produce an innings of substance to anchor England's chase.
South Africa were patient throughout the morning session and then pressed home their advantage late in the day to secure their first victory in five Tests.