England and West Indies second one-day international was abandoned after only 2.2 overs at Trent Bridge.
Jonny Bairstow scores maiden ODI century and Stokes took three for 43 ensured West Indies suffered a seven-wicket defeat at Old Trafford on Tuesday.
Visitors need to win the five-match ODI series by a margin of 5-0 or 4-0 for direct qualification for the 2019 global event.
Duo picked up six English batsmen as visitors defended 176 to win the one-off T20I after Gayle and Lewis set the agenda.
Ireland - West Indies one-off ODI at Stormont is abandoned after rain at lunchtime finally puts paid to hopes of any play.
James Anderson takes a career-best 7-42 to lead England to a series-clinching nine-wicket victory over West Indies and won series by 2-1.
West Indies take 22-run lead over England; James Anderson scalps 500th Test wicket.
James Anderson on Friday became the sixth bowler to pick 500 or more wickets in Test cricket.
England were struggling for 46/6 after they bowled out West Indies for 123 on a remarkable first day of the deciding Test.
After chase 322 in Leeds, visitors seek to topple England in series-decider.