Evin Lewis blazed his second hundred against India to lead the West Indies to a rampaging nine-wicket victory.
Chris Gayle is set for his first appearance for West Indies since April 2016.
India won the fifth and final ODI against West Indies by 8 wickets courtesy of a brilliant hundred by skipper Virat Kohli.
West Indies will be confident of being competitive and putting it past India again in the final match in Kingston on Thursday.
Chris Gayle back in West Indies squad for one-off T20I against India.
Jason Holder took five wickets to lead his side to a win by 11 runs over India.
MS Dhoni and Ajinkya Rahane starred with the bat while R Ashwin and Kuldeep Yadav bagged three wickets apiece.
West Indies could hand debut to Kyle Hope, Sunil Ambris in bid to keep series alive as it moves to Antigua.
India walked to a 105-run victory, their highest ODI margin of win in the Carribeans and have thus taken a 1-0 lead in the series.
The first ODI match between India and West Indies here on Friday was called off due to incessant rain.