Dublin: Tyrone Kane replaces Josh Little in the Irish attack with a 14-man squad named for the two one-day games against Afghanistan in Belfast.
Leinster Lightning paceman Kane could make his ODI debut in the Stormont matches on 19 and 21 May.
Little has been "rested" after suffering minor back pain in Ireland's disappointing Tri-Nations series.
Ireland were heavily defeated in all three of their completed games against West Indies and Bangladesh.
William Porterfield (c)