India 317 for 5 (Dhawan 98, Rahul 62*, Krunal 58*, Kohli 56, Stokes 3-34) beat England 251 (Bairstow 94, Krishna 4-54, Thakur 3-37) by 66 runs
Pune: England squandered the chance to win a fluctuating first one-day international against India, losing by 66 runs at Maharashtra Cricket Association Stadium, Pune on Tuesday.
Jonny Bairstow's scintillating 94, from only 66 balls, had the world champions well on course for their target of 318.
India's pace bowlers roared back, and an England side missing the rested Joe Root lost five wickets for 41 runs before eventually slumping to 251 all out.
The hosts had earlier been lifted to 317-5 by Shikhar Dhawan's 98 and 58 not out from Krunal Pandya, whose 26-ball half-century was the fastest by a debutant in one-day internationals.
On a bruising day, England captain Eoin Morgan spent time off the field with split webbing on his right hand, while Sam Billings sprained his collarbone joint attempting a stop on the boundary.
Rohit Sharma was struck on the elbow by Mark Wood and, most seriously, new Lancashire signing Shreyas Iyer suffered a partial dislocation of his left shoulder.
The second in the three-match series is on the same ground on Friday.
The one-day part of this long England tour carries the least significance when compared to the tourists' defeats in the Test and Twenty20 series, but the two top-ranked sides in the world still served up a compelling contest in an empty stadium.
Whereas England were carried to 2019 World Cup glory by their all-out aggression, India still favour an old-fashioned approach to 50-over cricket.
Their reliance on a late assault could have backfired had it not been for Krunal and KL Rahul, who capitalised as England lost their way when influential skipper Morgan was forced off in the 41st over.
The hosts had no answer to Bairstow's brutal hitting, only for a resurgence from their seamers to once again leave the game in the balance.
England were left relying on a lower order that has played little cricket, and they were gradually suffocated by their hosts.